Can realize 3D optoacoustic imaging of small animals in the NIR-I & NIR-II (660-2300 nm), high-resolution imaging of blood vessel morphology, and highly specific functional detection of different tissue components. Realizes multi-scale tracing and functional imaging from cells to tissue, and has important applications in many biomedical fields, such as molecular probes, bio-nanomaterials, cardiovascular diseases (angiogenesis, myocarditis, thrombosis, myocardial infarction,etc.), hemoglobin monitoring, early tumor detection and efficacy monitoring, sentinel lymph node monitoring, brain imaging and brain function monitoring and other frontier research.

• Development of bio-nano materials
  Development and application of
  photothermographic agents
  Development and application
  of bio-nano materials
  Biodistribution of nanoprobes
  Blood concentration
  …
• Targeted tumor imaging
  Subcutaneous tumor
  In situ tumors of the brain
  Orthotopic tumor of lower extremity
  Prostate tumor
  …
• Anatomy imaging
  Organs and spine
  Cardiovascular System
  Blood vessel microstructure
  Brain structure and blood vessels
  …
• Synergistic treatment
  Optoacoustic cavitation
  Photothermal and Acoustic
  Dynamics
  Optoacoustic and photochemistry
  …

Unlabeled optoacoustic imaging --Cerebral vascular imaging

Brain hemoglobin imaging can be used to detect brain tumors and traumatic brain injury (traumatic brain injury), and to monitor and evaluate the efficacy of cerebrovascular leakage, such as cerebral amyloidosis, stroke, etc.

OptoAcoustic Imaging of Live Mouse Brain,

Total Hemoglobin Map

R. Su et al. J. Biomed. Opt. 2012

Brain @1064nmLower Brain and Neck @760 nm

Unlabeled optoacoustic imaging --Microscopic vascular structure imaging

Microscopic hemoglobin angiography allows the observation of hematoma lesions and possible lesions and plaques in the surrounding area to detect cardiovascular diseases, such as atherosclerosis, myocarditis, thrombosis, myocardial infarction, etc.

Labeled optoacoustic imaging--bio-nanoprobe tumor imaging

TomoWave has been highly recognized by users since the introduction of the LOIS-3D NIR-I & NIR-II In vivo 3D Optoacoustic Imaging System. So far, it has been installed in the MD Anderson Cancer Research Center, Washington University in St. Louis, University of Houston, Qingdao University, Guangxi University and so on. We have cooperated with many scientific research teams such as Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Sun Yat-sen University, the Third Affiliated Hospital of Sun Yat-sen University, Huazhong University of Science and Technology, Soochow University, South China Normal University, Huazhong Agricultural University, Nanjing University of Technology, Nanjing University of Posts and Telecommunications, etc. The in vivo optoacoustic imaging characterization of the study was tested on the LOIS-3D NIR-I & NIR-II whole-body 3D optoacoustic imaging system for small animals.

NIR-I,non-photosensitive polymer nanovesicles for tumor therapy

Angew.Chem.Int.Ed. reported on a non-photosensitive material under the irradiation of pulsed laser to produce highly reactive substances, for cancer diagnosis and treatment. The fluorescence/optoacoustic dual-mode imaging of TomoWave's 3D optical system provides precise guidance for in-vivo pulsed laser therapy.

Angew. Chem. Int. Ed. 60,（2021）,4720-4731

Non-photosensitive polymer nanosicles (NO-NCPs) have the effect of optoacoustic cavitation to enhance ROS, and can accelerate the release of NO in acid lysosomes, thus providing highly reactive peroxide nitrite ONOO-, which promotes mitochondrial damage and DNA fragmentation of cancer cells, and thus apoptosis.

NIR-II,Study on tumor targeting of optoacoustic contrast agents

Small published a synthesis method of mini hollow gold nanorods (M-AuHNRs) with strong plasma absorbance. Under the same optical density, excited by TomoWave optoacoustic imaging system NIR-II, the optoacoustic signal intensity is 3.5 times stronger than that of ordinary hollow gold nanorods.

NIR-II, Photothermal and Acoustic Dynamic Synergy Therapy

Biomaterials reported a collaborative treatment method in NIR-II photothermal irradiation and ultrasound. Ir-B-TiO2@CCM realizes the tracking of the circulation of nanoparticles in the body under the mediation of multi-modal imaging, thereby monitoring the temperature change of the tumor during the treatment, and finally effectively inhibiting the tumor in the mouse animal model experiment metastasis and recurrence.