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TomoWave has been highly recognized by users since the introduction of the LOIS-3D NIR-I & NIR-II In vivo 3D Optoacoustic Imaging System. So far, it has been installed in the MD Anderson Cancer Research Center, Washington University in St. Louis, University of Houston, Qingdao University, Guangxi University and so on. We have cooperated with many scientific research teams such as Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Sun Yat-sen University, the Third Affiliated Hospital of Sun Yat-sen University, Huazhong University of Science and Technology, Soochow University, South China Normal University, Huazhong Agricultural University, Nanjing University of Technology, Nanjing University of Posts and Telecommunications, etc. The in vivo optoacoustic imaging characterization of the study was tested on the LOIS-3D NIR-I & NIR-II whole-body 3D optoacoustic imaging system for small animals.

NIR-II laser mediated photothermal therapy

AFM published a subminiature polypyrrole (PPY, ≈2nm) -based thermosensitive agent, showed significant tumor accumulation and effective renal clearance under NIR-II laser irradiation, with accurate and complete removal of mouse tumors.

Adv. Funct. Mater. 31,(2021),15

The kidney purgable ultra-small polypyrrole nanoparticles with size adjustment feature fluorescence/optoacoustic /NIR II multimode imaging with excellent photostability and photothermal conversion efficiency (808nm: 33.35%, 1064nm: 41.97%), has a large enrichment in the tumor and efficient renal metabolism, effectively killing the tumor in a low-toxic manner.

NIR-II optoacoustic imaging and photochemical synergistic therapy

Biomaterials proposed an activatable NIR-II phototherapy using miniature gold/silver nanorods (NRs) for photochemical synergistic treatment of MRSA infections and in-situ monitoring of the treatment process.

The ferrocyanide solution effectively activated Au/AgNRs and allowed the continuous release of free Ag+ to eliminate MRSA, triggering the enhancement of the photothermal and optoacoustic imaging performance of NIR-II. At the same time, the release of free Ag+ is accelerated, so as to facilitate the removal of Gram-positive Staphylococcus aureus and promote wound healing.
Biomaterials 251 ,(2020) ,120092

NIR-II multiin-one phototherapy

Journal of Controlled Release reported a method for the preparation of HBP/PTX micelles. This multifunctional photothermal technology enables NIR-II optoacoustic/fluorescent dual-mode imaging guided collaborative cancer therapy.

The HBP (hydrophobic ring-thickened-Azabodipy molecule)/PTX (Pluronic F127 as surfactant and hydrophobic paclitaxel) micelles exhibit strong fluorescence and absorbance, excellent photothermal conversion and photostability in the NIR-II window. In addition, real-time lymph node and tumor tracking was achieved in tumor-bearing mice. This multifunctional photothermal technique makes it possible for NIR-II fluorescence/optoacoustic bipeak imaging to guide collaborative cancer therapy.
Journal of Controlled Release 326 ,(2020), 256–264

NIR-II optoacoustic imaging and low temperature photothermal therapy

Chem.Commun reported a coordinated treatment method of photothermal irradiation and ultrasound in NIR-II. Ir-B-TiO2@CCM realizes the tracking of the circulation of nanoparticles in the body under the mediation of multi-modal imaging, thereby monitoring the temperature change of the tumor during the treatment process, and effectively inhibiting the metastasis of the tumor in the mouse animal model relapse.

A new strategy for low-temperature nuclear targeting of PTT was introduced in the NIR-II region. The new subminiature chitosan coated nanoparticles (CS-RuO2NP) with intrinsic nuclear targeting properties showed strong absorbability and high photothermal conversion efficiency in the NIR-II window, making them potential candidates for photothermal agents and optoacoustic imaging (PAI) reagents.
Chemical Communications 56,( 2020) ,20
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